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Two-stage multi-objective optimization for ICU bed allocation under multiple sources of uncertainty

Fang Wan, Julien Fondrevelle, Tao Wang, Antoine Duclos

Scientific Reports

Extra respiratory comorbidities in adult patients with cystic fibrosis

Abstract not available

The promise of combining CDK4/6 inhibition with hormonal therapy in the first-line treatment setting for metastatic or recurrent endometrial adenocarcinoma

Metastatic or recurrent endometrioid adenocarcinoma of the uterine corpus is often incurable with limited treatment options. First-line treatment often includes cytotoxic chemotherapy, which incurs significant toxicities for many patients.

What do mothers think about their antenatal classes? A mixed-method study in Switzerland

Problem: Research so far has evaluated the effect of antenatal classes, but few studies have investigated its usefulness from the perspective of mothers after birth.

Factors perceived by health professionals to be barriers or facilitators to caries prevention in children: a systematic review

Background: Considered the most prevalent noncommunicable disease in childhood, dental caries is both an individual and a collective burden.

Influence of the embedded participant on learners' performance during high-fidelity simulation sessions in healthcare

International collaboration with the Department of Emergency Medicine, Ankara University School of Medicine, Ankara, Turkey

Background: The embedded participant (EP) plays a key role during a full scale/high-fidelity simulation (HFS) session. He/she is expected to guide the learner towards the achievement of the educational objectives of the scenario. 

Decision-making process of withholding or withdrawing life-sustaining treatments in French emergency departments during COVID-19 outbreak


Trajectories of Controller Therapy Use Before and After Asthma-Related Hospitalization in Children and Adults: Population-Based Retrospective Cohort Study

Background: Inappropriate use of inhaled corticosteroids (ICSs) for asthma impairs control and may cause exacerbation, including asthma-related hospitalization (ARH). In prospective studies, ICS use peaked around ARH, but information on routine care use is limited. Since ARH is a major outcome, controller therapy use in routine care before and after ARH should be documented.

Ethical issues encountered by French intensive care unit caregivers during the first COVID-19 outbreak

Purpose: We aimed to describe the ethical issues encountered by health care workers during the first COVID-19 outbreak in French intensive care units (ICUs), and the factors associated with their emergence.

Using patient comments from a standardised experience survey to investigate their perceptions and prioritise improvement actions: a thematic and syntactic analysis

Background: Although patient experience surveys flourish in many countries with the aim to improve quality of care, questions remain concerning their ability to become effective drivers of change within institutions. The patient comments from the French national patient experience hospital survey were analysed using an innovative structured approach to characterise patient experience and identify field actions for the institutions.

Risk factors and mortality associated with undertriage after major trauma in a physician-led prehospital system: a retrospective multicentre cohort study

Purpose: To assess the incidence of undertriage in major trauma, its determinant, and association with mortality.

Perception of barriers and facilitators in the continuity of care for precarious migrants in general practice

Introduction : Continuity of care is essential for the diagnosis and treatment of somatic and mental conditions in precarious migrants. This study explored the barriers and facilitators in the continuity of care provided to precarious migrants in general practice.

Economic analysis of surgical outcome monitoring using control charts: the SHEWHART cluster randomised trial

Importance: Surgical complications represent a considerable proportion of hospital expenses. Therefore, interventions that improve surgical outcomes could reduce healthcare costs.

Medical assistance in dying law: a qualitative study of French cancer physicians

Objectives: The legal landscape surrounding end-of-life care in France is subject to frequent changes. A proposed law to legalise euthanasia in April 2021 has raised questions about the role of physicians. If enacted, oncologists would likely be among the first professionals impacted, as data from countries with legalised euthanasia reveal that patients with cancer constitute the majority of those seeking this option.

The impact of shift work on pain recognition, a robust ability among intensive care nurses

Background : Pain empathy is essential for high-quality of care. The cognitive ability to identify and understand the pain in others remains underexplored in the context of hospital shift work. This study aimed to observe the early subliminal ability to detect pain in other faces and to investigate pain intensity evaluations during day and night shifts.

Determinants of Care Pathways for C-PTSD Patients in French Psychotrauma Centers: A Qualitative Study

In 2018, the International Classification of Diseases (ICD-11) established a novel nosographic category within the stress-specific disorders known as complex post-traumatic stress disorder (C-PTSD). Characterized by distinctive clinical attributes and a limited response to conventional PTSD treatments, C-PTSD has prompted the reconsideration of care methods.

Recurrence after Surgery for Primary Hyperparathyroidism in 517 Patients with Multiple Endocrine Neoplasia Type 1. An AFCE and GTE study

Objective: To assess recurrence according to the type of surgery for primary hyperparathyroidism (pHPT) in MEN1 patients and to identify the risk factors for recurrence after initial surgery.

Treatments for rare ovarian tumors: What's new?

Even if each rare ovarian tumor (ROT) has a low incidence, the sum of all these entities represents almost the half of all ovarian neoplasms. Thus, development of dedicated clinical trial emerged as a prerequisite to improve their managements.

Prevalence of Positive QuantiFERON-TB Test among Sarcoid Uveitis Patients and its Clinical Implications in a Country Non-endemic for Tuberculosis

Aim: To report on the prevalence and clinical implications of positive QuantiFERON-TB (QFT) test results in the diagnostic evaluation of a cohort of consecutive sarcoid uveitis patients in France.

Value of Chest X-Ray and Chest Computed Tomography for Systemic Sarcoidosis Diagnosis in Undifferentiated Uveitis

Background: To evaluate the contribution of chest X-ray and chest CT for the diagnosis of sarcoid uveitis.

Chronic pain characteristics in COVID-19 survivors after an ICU stay. A cross-sectional study

Background: The onset and characteristics of chronic pain following an intensive care unit (ICU) stay for COVID-19 have never been thoroughly investigated.

Outcome of patients with cystic fibrosis colonized by Scedosporium and Lomentospora species: A longitudinal cohort study

Scedosporium and Lomentospora species rank second among the filamentous fungi colonizing the airways of cystic fibrosis (CF) patients. These fungi could be responsible for allergic bronchopulmonary mycosis (ABPM) and bronchitis before lung transplantation and invasive infections after. However, their role in CF lung disease is debated.

Veno-arterial extracorporeal membrane oxygenation for cardiogenic shock after acute myocardial infarction: Insights from a French nationwide database

Background: We aimed to analyze the impact of timing of implantation (strategy-outcome relationship) and volume of procedures (volume-outcome relationship) on survival of veno-arterial extracorporeal membrane oxygenation (VA ECMO) for cardiogenic shock complicating acute myocardial infarction (AMI).

PARP inhibitors (PARPi) prolongation after local therapy for oligo-metastatic progression in relapsed ovarian cancer patients

Background: PARP inhibitors (PARPi) have revolutionized the management of high-grade epithelial ovarian cancer (HGOC) treatment. However, a significant number of patients relapse or progress under PARPi, leading to the introduction of a new line of systemic therapy such as chemotherapy.

Frequency and determinants of technical procedures in French general practice : a cross-sectional study

Introduction: Technical skills have many areas of application in general practice and are a dimension of medical competence. Several studies have attempted to describe the technical procedures performed in general practice but most had limitations in the data collection process, the scope of the procedures addressed, or the healthcare actors involved.

Impact of the 2015 European guidelines for resuscitation on traumatic cardiac arrest outcomes and prehospital management: A French nationwide interrupted time-series analysis

Aim: To evaluate the impact of the 2015 European Resuscitation Council (ERC) guidelines on patient outcomes following traumatic cardiac arrest (TCA) and on advanced life support interventions carried out by physician-staffed ambulances.

Continued Performance Improvement-What Practicing Surgeons Can Learn From Athletes

Top athletes and surgeons both continuously try to improve their performance. Athletes use a combination of strategies including coaching, feedback, preparation, and recuperation, to continually progress, to prolong their careers, and ultimately to win as many competitions as possible.

Parental experience of parent-mediated intervention for children with ASD: A systematic review and qualitative evidence synthesis

The effectiveness of parent-mediated interventions in the field of autism spectrum disorder is well documented but information on the experience of parents involved in parent-mediated interventions is limited.

Potentially inappropriate medications and anticholinergic and sedative burden in older community-dwelling patients with advanced chronic kidney disease

Objective: Regarding older patients, multiple chronic conditions lead to the intake of multiple medications, involving a higher risk of adverse drug events. In older patients with advanced chronic kidney disease, the medication exposure was poorly explored.

Learning motivational interviewing to better support patient medication adherence

Motivational interviewing (MI), developed in the 1980s, demonstrated efficacy in helping patients to change their health behavior, and more recently in supporting patient therapeutic adherence.

Safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH)

The PEACH study, carried out within RESHAPE, received on April 5, 2023 the prize for excellence in neurology awarded by the French Society of Neurology.

Disrespect during childbirth and postpartum mental health: a French cohort study

Background: While the World Health Organisation (WHO) warned about mistreatment, disrespect and/or abuse during childbirth as early as 2014. This same year a social media movement with #payetonuterus brought to light the problematic of obstetrical violence in French speaking countries, and more specifically on issues of disrespect.

Individual and environmental determinants associated with longer times to access pediatric rheumatology centers for patients with juvenile idiopathic arthritis, a JIR cohort study

Background: This project assesses socio-economic factors of delayed referral to a pediatric rheumatologist (PRst) for JIA patients in France and Switzerland within the Juvenile Inflammatory Rheumatism (JIR) Cohort.

Barrier measures implemented in French maternity hospitals during the COVID-19 pandemic: A cross-sectional survey

Objectives: The objectives of this survey were 1) to describe the changes over time of barrier measures in maternity units, specifically, co-parent visits and women wearing masks in birth rooms, and 2) to identify potential institutional determinants of these barrier measures.

Control Charts Usage for Monitoring Performance in Surgery: A Systematic Review

Objectives: The control chart is a graphical tool for data interpretation that detects aberrant variations in specific metrics, ideally leading to the identification of special causes that can be resolved. A clear assessment of control chart utilization and its potential impact in surgery is required to justify recommendations for its dissemination. This review aims to describe how performance monitoring using control charts was used over time in surgery.

A conceptual framework to develop a patient-reported experience questionnaire on the cystic fibrosis journey in France: the ExPaParM collaborative study

Background: The objective of the study was to elaborate a conceptual framework related to the domains of patient experience along the cystic fibrosis (CF) journey from the patients and parents of children with CF to inform the design of a patient-reported experience questionnaire.

Evaluation of a training program for emergency medical service physician dispatchers to reduce emergency departments visits

Background: Emergency Departments (ED) have seen an increasing number of older patients who are mostly referred following a call to the Emergency Medical Services (EMS).

Evaluation of Midwives' Practises on Herpetic Infections during Pregnancy: A French Vignette-Based Study

Background: One out of two pregnant women has a history of herpes infection. Initial infections have a high risk of neonatal transmission. Our objective was to analyse the professional practises of midwives regarding the management of herpes infections during pregnancy in France.

Accuracy of a Prehospital Triage Protocol in Predicting In-Hospital Mortality and Severe Trauma Cases among Older Adults

Background: Prehospital trauma triage tools are not tailored to identify severely injured older adults. Our trauma triage protocol based on a three-tier trauma severity grading system (A, B, and C) has never been studied in this population.

Use of a Digital Cognitive Aid Improves Memorization of Military Caregivers After High-Fidelity Simulations of Combat Casualty Care

Introduction: High-fidelity simulation is widely used in the ongoing education of caregivers. However, the complex high-stakes simulated crisis environment affects memorization. This study investigated whether participants would remember more key training messages 3 months after a simulated complex emergency situation if they had used a digital cognitive aid (CA) during the simulations.

Barriers and Facilitators to the Use of Clinical Decision Support Systems in Primary Care: A Mixed-Methods Systematic Review

Purpose: To identify and quantify the barriers and facilitators to the use of clinical decision support systems (CDSSs) by primary care professionals (PCPs).

Emergency calls concerning older patients : Are the appropriate questions asked ?

Aim: In the present study, we evaluated the triage process particularly for older patients after calls to Emergency Medical Call Centers (ECC), according to the geriatric assessment tool.

Rehabilitation professionals' views on individual peer support interventions for assisting stroke survivors with reintegration into the community: a qualitative study

Purpose: We aimed to explore stroke rehabilitation professionals' understanding and representations of peer support; the benefits they anticipated for patients; and the levers and barriers they perceived to implement the intervention in their practice.

Impact of early palliative care on additional line of chemotherapy in metastatic breast cancer patients: results from the randomized study OSS

Purpose: The most appropriate criteria and timing for palliative care referral remain a critical issue, especially in patients with metastatic breast cancer for whom long-term chemosensibility and survival are observed. We aimed to compare the impact of early palliative care including formal concertation with oncologists on decision for an additional line of chemotherapy compared with usual oncology care.

Efficacy and safety of maintenance olaparib and bevacizumab in ovarian cancer patients aged ≥65 years from the PAOLA-1/ENGOT-ov25 trial

Sabatier R, Rousseau F, Joly F, Cropet C, Montégut C, Frindte J, Cinieri S, Guerra Alía EM, Polterauer S, Yoshida H, Vergote I, Colombo N, Hietanen S, Largillier R, Canzler U, Gratet A, Marmé...

Association between location of out-of-hospital cardiac arrest, on-scene socioeconomic status, and accessibility to public automated defibrillators in two large metropolitan areas in Canada and France

Heidet M, Freyssenge J, Claustre C, Deakin J, Helmer J, Thomas-Lamotte B, Wohl M, Danny Liang L, Hubert H, Baert V, Vilhelm C, Fraticelli L, Mermet É, Benhamed A, Revaux F, Lecarpentier É,...

Nurse-to-Nurse Familiarity and Mortality in the Critically Ill. A Multicenter Observational Study

Duclos A, Payet C, Baboi L, Allaouchiche B, Argaud L, Aubrun F, Bohé J, Dailler F, Fellahi JL, Lehot JJ, Piriou V, Rimmelé T, Terragrossa D, Polazzi S, Guérin C.

Am J Respir Crit Care Med. 2022...

Comparative non-persistence in the first year of treatment with oral anticoagulants in patients with atrial fibrillation: A French comprehensive nationwide study

Danchin N, Steg G, Mahé I, Hanon O, Jacoud F, Nolin M, Dalon F, Cotte FE, Gollety S, Van Ganse E, Belhassen M

Arch Cardiovasc Dis. 2022 Sep. Online ahead of print. 


Background: Direct...

The Needs, Use and Expectations of People Bereaved by Suicide Regarding Online Resources: An Online Survey

Leaune E, Rouzé H, Lestienne L, Bislimi K, Chalancon B, Morgiève M, Grandgenèvre P, Vaiva G, Laplace N, Poulet E, Haesebaert J.

Int J Environ Res Public Health. 2022 Sep. 


Pregnancy, Mental Well-Being and Lockdown: A Nationwide Online Survey in France

Gaucher L, Barasinski C, Dupont C, Razurel C, Pichon S, Leavy E, Viaux-Savelon S, Cortet M, Franck N, Haesebaert F, Haesebaert J.

Healthcare (Basel). 2022 Sep

Abstract:The objective of this study...

Factors associated with post-stroke social participation: a quantitative study based on the ICF framework

Della Vecchia C, Préau M, Haesebaert J, Viprey M, Rode G, Termoz A, Dima A, Schott AM

Annals of physical and rehabilitation medicine/ June 2022 Online ahead of print.



Barriers and Facilitators to Participation in Health Screening: an Umbrella Review Across Conditions

Le Bonniec A, Sun S, Andrin A, Dima AL, Letrilliart L.

Prevention science June 2022 Epub ahead of print


Screening is an essential prevention practice for a number of health conditions....

Potentially inappropriate medications and anticholinergic and sedative burden in older patients with haemophilia or von Willebrand disease: The M'HEMORRH-AGE study

Novais T, Prudent C, Cransac A, Gervais F, Mouchoux C, Gigan M, Cahoreau V, Jouglen J, Chamouard V

Journal of Clinical Pharmacy and Therapeutics / June 2022


What is known and...

Prehospital trauma flowcharts - Concise and visual cognitive aids for prehospital trauma management from the French Society of Emergency Medicine (SFMU) and the French Society of Anaesthesia and Intensive Care Medicine (SFAR)

Tazarourte K, Ageron FX, Avondo A, Barnard E, Bobbia X, Cesareo E, Chollet- Xemard C, Curac S, Desmettre T, Khoury CEL, Gauss T, Gil-Jardine C, Harris T, Heidet M, Lapostolle F, Pradeau C, Renard...

Impact of COVID-19 on chronic pain structures: data from French national survey

Melchior M, Dziadzko M, Conradi S, Poisbeau P, Aubrun F

Journal of Comparative Effectiveness Research / June 2022


Aims: The authors evaluated the impact of the first COVID-19 pandemic...

Minimum evidence-based care in intrauterine growth-restricted fetuses and neonatal prognosis

Atallah A, Butin M, Moret S, Claris O, Massoud M, Gaucherand P, Doret-Dion M.

Archives of Gynecology and Obstetrics  / May 2022


Background: Introduction: There is clear evidence that...

Diagnostic value of lumbar puncture for the etiological assessment of uveitis: a retrospective cohort of 188 patients

Bernier R, Gavoille A, Chirpaz N, Jamilloux Y, Kodjikian L, Mathis T, Sève P.

Graefe's Archive for Clinical and Experimental Ophthalmology / May 2022


Aim: To assess the relevance of...

Methodological considerations on estimating medication adherence from self-report, electronic monitoring and electronic healthcare databases using the TEOS framework

Dima AL, Allemann SS, Dunbar-Jacob J, Hughes DA, Vrijens B, Wilson IB

British Journal of Clinical Pharmacology / May 2022


Aims: Measuring adherence to medication is complex due to the...

Co-design and evaluation of a patient-centred transition programme for stroke patients, combining case management and access to an internet information platform: study protocol for a randomized controlled trial - NAVISTROKE

Termoz A, Delvallée M, Damiolini E, Marchal M, Preau M, Huchon L, Mazza S, Habchi O, Bravant E, Derex L, Nighoghossian N, Cakmak S, Rabilloud M, Denis A, Schott AM, Haesebaert J

BMC Health...

Developing a medication adherence technologies repository: proposed structure and protocol for an online real-time Delphi study

Nabergoj Makovec U, Goetzinger C, Ribaut J, Barnestein-Fonseca P, Haupenthal F, Herdeiro MT, Grant SP, Jácome C, Roque F, Smits D, Tadic I, Dima AL

BMJ Open / April 2022


Reasons for acceptance and refusal of early palliative care in patients included in early-phase clinical trials in a regional comprehensive cancer centre in France: protocol for a qualitative study

Chvetzoff G, Girodet M, Despax J, Baudry V, Duranti J, Mastroianni B, Vanacker H, Vinceneux A, Brahmi M, Renard O, Gautier J, Britel M, Ducimetière F,

Anota A, Cassier P, Christophe V

BMJ Open /...

Prehospital predictors for return of spontaneous circulation in traumatic cardiac arrest

Benhamed A, Canon V, Mercier E, Heidet M, Gossiome A, Savary D, El Khoury C, Gueugniaud PY, Hubert H, Tazarourte K

Journal of Trauma and Acute Care Surgery / March 2022


Analyzing the Difficulties of Continuing Physical Activity during the COVID-19 Crisis in France

Dumoulin C, Havet N, Lesueur JY.

International Journal of Environmental Research and Public Health / March 2022


Physical activity (PA) and limiting sedentary behavior have been...

Implementation of an in situ simulation-based training adapted from Morbidity and Mortality conference cases: effect on the occurrence of adverse events-study protocol of a cluster randomised controlled trial

Michel N, Bui-Xuan B, Bapteste L, Rimmele T, Lilot M, Chollet F, Favre H, Duclos A, Michel P

Trials / February 2022


Background: Morbidity and Mortality conference provides the necessary...

Temporal trends in reperfusion therapy for patients with acute ischemic stroke

El Khoury C, Aboa-Eboule C, Fraticelli L, Claustre C, Bischoff M, Blanc- Lasserre K, Buisson M, Cakmak S, Cho TH, Ferroud-Plattet B, Guerrier O,

Philippeau F, Serre P, Mechtouff L, Nighoghossian...

Is it possible to improve prediction of outcome and blood requirements in the severely injured patients by defining categories of coagulopathy ?

David JS, Friggeri A, Vacheron CH, Bouzat P, Fraticelli L, Claustre C, Maegele M, Inaba K

European Journal of Trauma and Emergency Surgery / February 2022


Purpose: It has been suggested...

Temporal trends in healthcare resource use and associated costs of patients with cystic fibrosis

Durieu I, Dalon F, Reynaud Q, Lemonnier L, Dehillotte C, Bérard M, Walther D, Viprey M, Van Ganse E, Belhassen M

Journal of Cystic Fibrosis / January 2022


Background: Better insights...

Mortality Among Noncoronavirus Disease 2019 Critically Ill Patients Attributable to the Pandemic in France

Payet C, Polazzi S, Rimmelé T, Duclos A

Critical care medicine / January 2022


Objectives: We investigated whether the risk of death among noncoronavirus disease 2019 critically ill...

External validation of the Hospital Frailty Risk Score in France

Gilbert T, Cordier Q, Polazzi S, Bonnefoy M, Keeble E, Street A, Conroy S, Duclos A.

Age Ageing / January 2022


Background: The Hospital Frailty Risk Score (HFRS) has made it possible...

Prevalence of low health literacy levels in decompensated heart failure compared with acute myocardial infarction patients

Adèle Perrin, Gergis Abdalla, Marie Viprey, François Delahaye, Nathan Mewton, Michel Ovize, Laurent Sebbag, Thomas Bochaton, Alexandra L. Dima, Estelle Bravant, Anne-Marie Schott, Julie...

High-dimensional propensity scores improved the control of indication bias in surgical comparative effectiveness studies

Cécile Payet, Stéphanie Polazzi, Jean-François Obadia, Xavier Armoiry, José Labarère, Muriel Rabilloud, Antoine Duclos.

Journal of Clinical Epidemiology / February 2021


Organizational aspects of care associated with mortality in critically ill COVID-19 patients

Thomas Rimmelé, Léa Pascal, Stéphanie Polazzi, Antoine Duclos.

Intensive Care Medicine / January 2021

No abstract available.

See publication

Standardized healthcare pathway in intrauterine growth restriction and minimum evidence-based care

Atallah A, Butin M, Moret S, Claris O, Massoud M, Gaucherand P, Doret-Dion M. 

Journal of Gynecology Obstetrics and Human Reproduction / January 2021


Introduction: Fetal growth...

Using the Brief Health Literacy Screen in Chronic Care in French Hospital Settings: Content Validity of Patient and Healthcare Professional Reports

Adèle Perrin, Luiza Siqueira do Prado, Amélie Duché, Anne-Marie Schott, Alexandra L. Dima and Julie Haesebaert.

International Journal of Environmental Research and Public Health / December...

Effect of monitoring surgical outcomes using control charts to reduce major adverse events in patients: cluster randomised

Antoine Duclos, François Chollet, Léa Pascal, Hector Ormando, Matthew J Carty, Stéphanie Polazzi, Jean-Christophe Lifante, SHEWHART Trial Group.

BMJ / November 2020


Objective: To...

Beyond the map: evidencing the spatial dimension of health inequalities

Yohan Fayet, Delphine Praud, Béatrice Fervers, Isabelle Ray-Coquard, Jean-Yves Blay, Françoise Ducimetiere, Guy Fagherazzi and Elodie Faure.

International Journal of Health Geographics /...

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