Chargari C, Martinez A, Michels J, Lecuru F, Combe P, Kurtz JE, Bello-Roufai D, Prulhière K, Genestie C, Balleyguier C, Ducassou A, Demontoy S, Joly F, Frenel JS, Berton D, Rousset-Jablonski C, Ray-Coquard I.
Bull Cancer . 2026 Feb;113(2):208-223.
doi: 10.1016/j.bulcan.2026.01.004.
PMID: 41617621
ABSTRACT
Localized or locally advanced cervical cancer is treated with a curative intent. Its management requires multidisciplinary expertise and a rigorously structured approach to optimize the probability of success. Initial workup (clinical examination, imaging, pathology) allows precise characterization of the tumour and staging according to TNM and FIGO classifications. Surgical management of early stage cancers, ranging from conization for small tumour to hysterectomy, sometimes including sentinel lymph node biopsy, is based on therapeutic algorithms that take into account stage, pathological criteria (invasion, margins, node involvement) and risk category. Postoperative treatment, when required, includes radiochemotherapy, that can be followed by brachytherapy. In locally advanced cancers, treatment consists of radiochemotherapy followed by uterovaginal brachytherapy and immunotherapy that has recently demonstrated its benefits. Since cervical cancer often develops in young women, its management raises important questions related to fertility and sometimes, to the management of cancer during pregnancy. Finally, although it is not the topic of these recommendations, it is important to highlight the major role of vaccination to avoid the vast majority of these cancers.
Keywords: Brachytherapy; Cancer du col utérin; Cervical uterine cancer; Diagnostic; Localized stage conization; Pregnancy; Stade localisé; Traitements; Vaccination.
